SH3BP5 Antibody, HRP conjugated

Datasheet

Code	CSB-PA021226LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SH3BP5 Polyclonal antibody

Uniprot No.

O60239

Target Names

SH3BP5

Alternative Names

3BP5_HUMAN antibody; OTTHUMP00000208289 antibody; OTTHUMP00000208291 antibody; OTTHUMP00000208294 antibody; SAB antibody; SH3 binding protein antibody; SH3 domain binding protein 5 (BTK associated) antibody; SH3 domain binding protein 5 antibody; SH3 domain binding protein that preferentially associates with BTK antibody; SH3 domain-binding protein 5 antibody; SH3 domain-binding protein that preferentially associates with BTK antibody; SH3 domainbinding protein 5 antibody; SH3BP 5 antibody; SH3BP-5 antibody; Sh3bp5 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human SH3 domain-binding protein 5 protein (49-455AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Gene References into Functions

SH3BP5, LMO3, and SNAP25 were expressed in diffuse large B-cell lymphoma cells and associated with clinical features. PMID: 27184832
REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11. PMID: 26745340
The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis. PMID: 25666017
SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs). PMID: 23861391
mitochondrial protein Sab is phosphorylated by stress-activated protein kinase 3 PMID: 15158451

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Subcellular Location

Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion.

Protein Families

SH3BP5 family

Tissue Specificity

Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.

Database Links

HGNC: 10827

OMIM: 605612

KEGG: hsa:9467

STRING: 9606.ENSP00000373301

UniGene: Hs.257761

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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